The calcitonin‐like sequence of the β CGRP gene

FEBS Letters

Rassool, Feyruz V.²  Legon, Steve¹  Shiraishi, Akio¹  Maclntyre, Iain¹  Alevizaki, Maria¹  Ferner, Gwendolynn J.M.¹ 

[1] Dept of Chemical Pathology, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London W12 OHS, England;MRC Leukaemia Unit, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London W12 OHS, England

关键词: Calcitonin gene related peptide βCGRP gene;    Calcitonin;    Gene duplication;   

DOI  :  10.1016/0014-5793(86)81338-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have identified a region within the β CGRP gene which has the potential to encode a novel calcitonin-like peptide. The gene is located on the short arm of chromosome 11 (11p 12–14.2) and we suggest that it resulted from a local duplication of the α gene. We have been unable to detect the corresponding mRNA in a variety of tissues which express α-calcitonin. It is not clear whether this sequence can be expressed in man.

【 授权许可】

Unknown