A third human CALC (pseudo)gene on chromosome 11

FEBS Letters

Lips, C.J.M.¹  Adema, G.J.³  Jansz, H.S.¹  Steenbergh, P.H.³  Zandberg, J.³  van Kessel, A.H.M.Geurts²  Höppener, J.W.M.¹ 

[1]Institute of Molecular Biology, State University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands

[2]Department of Cell Biology and Genetics, Erasmus University, PB 1738, 3000 DR Rotterdam, The Netherlands

[3]Laboratory for Physiological Chemistry, State University of Utrecht, Vondellaan 24, 3521 GG Utrecht, The Netherlands

关键词: Calcitonin;    Gene duplication;    CALC-III (pseudo)gene;    Chromosomal localization;    (Man);   

DOI  :  10.1016/0014-5793(88)81355-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A genomic locus in man (CALC-III) containing nucleotide sequences highly homologous to both exon 2 and exon 3 of the CALC-I and -II genes, is described in this paper. The CALC-I gene produces calcitonin (CT) (encoded by exon 4) or calcitonin gene-related peptide (CGRP) (encoded by exon 5) in a tissue-specific fashion. The CALC-II gene produces a second human CGRP, but probably not a second CT. The CALC-III gene does not seem to encode a CT- or CGRP-related polypeptide hormone and is probably a pseudogene. Like the other two CALC genes, the CALC-III gene is located on human chromosome 11.

【 授权许可】

Unknown