Interactions of tuftsin with bovine serum albumin

FEBS Letters

Bhakuni, Vinod¹  Gupta, C.M.¹ 

[1] Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001, India

关键词: Tuftsin (Blood) Peptide stability Albumin Macrophage;    BSA;    bovine serum albumin;    PBS;    phosphate-buffered saline;    CD;    circular dichroism;   

DOI  :  10.1016/0014-5793(86)80926-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interactions of tuftsin (Thr-Lys-Pro-Arg) with bovine serum albumin (BSA) were analysed by fluorescence spectroscopy and circular dichroism. The data show that tuftsin interacts weakly with BSA, but this interaction is considerably enhanced by introducing an apolar substituent at the C-terminus of the tetrapeptide. It is suggested that strong binding of tuftsin to albumin in blood may enhance its macrophage-stimulating activity in vivo.

【 授权许可】

Unknown