Inhibition by interferon (α + β) of mouse liver regeneration and its reversal by putrescine

FEBS Letters

Kobayashi, Kenzo¹  Matsui-Yuasa, Isao¹  Nishiguchi, Shuhei¹  Otani, Shuzo¹  Monna, Takeyuki¹  Yamamoto, Sukeo¹  Morisawa, Seiji¹  Kuroki, Tetsuo¹ 

[1] Department of Biochemistry, Osaka City University Medical School, Asahimachi, Abeno-ku, Osaka 545, Japan

关键词: Interferon;    2';    5'-Oligoadenylate;    Putrescine;    Partial hepatectomy;    Liver regeneration;    (Mouse);    IFN;    interferon;    2-5A;    2';    5'-oligoadenylate;    i.p.;    intraperitoneally;   

DOI  :  10.1016/0014-5793(86)80866-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Mouse interferon (α + β) given to mice by intraperitoneal injection suppressed both the accumulation of putrescine and stimulation of DNA synthesis in liver caused by partial hepatectomy. The suppression of DNA synthesis was completely reversed by exogenous putrescine. The same results were obtained when core 2',5'-oligoadenylate instead of interferon was given to partially hepatectomized mice. These results suggest that interferon inhibits putrescine formation through elevating the 2',5'-oligoadenylate level and thus inhibits DNA synthesis in the regenerating liver.

【 授权许可】

Unknown