Binding of transferrin‐iron by adriamycin at acidic pH

FEBS Letters

Nørskov-Lauritsen, Niels¹  Demant, Erland J.F.¹ 

[1] Department of Biochemistry C, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark

关键词: Adriamycin Transferrin (Human serum) Adriamycin-Fe3+ complex;    ADM;    adriamycin;    Tr;    transferrin;    Fe-Tr;    iron-loaded transferrin;   

DOI  :  10.1016/0014-5793(86)80271-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is shown that adriamycin is able to chelate iron released from iron-loaded serum transferrin in the pH range from 6.5-4.1. The kinetics of iron transfer to free adriamycin and to adriamycin covalently attached to the transferrin has been determined. The results show that adriamycin, if introduced into intracellular acidic compartments, could function as acceptor for transferrin-iron.

【 授权许可】

Unknown