Cell nuclei generate DNA‐nicking Superoxide radicals

FEBS Letters

Peskin, Alexander V.¹  Shlyahova, Larisa¹ 

[1] N.K. Koltsov Institute of Developmental Biology, USSR Academy of Sciences, Moscow GSP-1 117808, USSR

关键词: Superoxide generation;    NADPH oxidation;    DNA damage;    Active oxygen species;    (Rat liver nucleus);    SOD;    Superoxide dismutase;   

DOI  :  10.1016/0014-5793(86)80109-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rat liver nuclei generate Superoxide radicals in the presence of NADPH. Active oxygen species induced nicks in nuclear DNA. This was prevented by Superoxide dismutase and catalase as well as by anaerobiosis. EDTA-Fe³⁺ dramatically increased the active oxygen-dependent DNA nicking.

【 授权许可】

Unknown