T7 and E.coli share homology for replication‐related gene products

FEBS Letters

Toh, Hiroyuki¹ 

[1] Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan

关键词: Bacteriophage T7;    Homology;    5'-3'-Exonuclease;    DNA primase;    DNA polymerase I;    Helix-destabilizing protein;   

DOI  :  10.1016/0014-5793(86)80093-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recently, the complete nucleotide sequence of the bacteriophage T7 genome was determined and 50 genes were identified on the genome. We compared amino acid sequences of all the gene products of T7 and replication-related gene products of E.coli. As a result, we found that T7 and E.coli share homology for each pair of exonuclease, DNA primase and helix-destabilizing protein. For E.coli, these gene products are known to be involved in the process of discontinuous DNA replication. These observations suggest that T7 and E.coli have a common origin for a part of their replication systems.

【 授权许可】

Unknown