Mechanisms underlying the asynchronous replacement of myosin light chain isoforms during stimulation‐induced fibre‐type transformation of skeletal muscle

FEBS Letters

Salmons, Stanley¹  Whalen, Robert G.²  Brown, Wendy E.¹ 

[1] Department of Anatomy, University of Birmingham, Birmingham B15 2TJ, England;Departément de Biologie Moléculaire, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris, France

关键词: Myosin light chain;    Polymorphism;    Muscle;    Stimulation;   

DOI  :  10.1016/0014-5793(85)80114-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

During the fibre-type transformation induced by chronic electrical stimulation of rabbit fast-twitch muscle, replacement of the fast forms of the two classes of myosin light chain by their slow isoforms occurs asynchronously. Studies of total cellular myosin light chains and of the slow-to-fast transition now justify the conclusion that the asynchrony is due to switching between the expression of fast and slow genes for the two light chain classes at sequential stages of the transformation process.

【 授权许可】

Unknown