Myeloperoxidase oxidation of sulfur‐centered and benzoic acid hydroxyl radical scavengers

FEBS Letters

Eicher, Alisa L.¹  Green, Terrence R.¹  Fellman, Jack H.¹ 

[1] Department of Biochemistry, Oregon Health Sciences University and Clinical Pathology Service, Veterans Administration Medical Center, Portland, OR 97201, USA

关键词: Myeloperoxidase;    Hydroxyl radical;    Neutrophil;    Hypochlorous acid;    Benzoate decarboxylation;   

DOI  :  10.1016/0014-5793(85)80037-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Myeloperoxidase (MPO) oxidizes sulfur-centered and benzoate hydroxyl radical scavengers through formation of HOCl. Sulfur-centered hydroxyl radical scavengers compete with benzoate as antioxidants ofHOCl. We conclude from these observations that competition experiments between benzoate and sulfur-centered hydroxyl radical scavengers are not sufficiently specific to infer participation of hydroxyl radicals in oxidative reactions mediated by neutrophils because of the unique action of MPO in affecting oxidation of the test radical scavengers.

【 授权许可】

Unknown