Biologically significant scavenging of the myeloperoxidase‐derived oxidant hypochlorous acid by ascorbic acid

FEBS Letters

Grootveld, Martin¹  Wasil, Mohammed¹  Halliwell, Barry¹ 

[1] Department of Biochemistry, King's College (KQC), Strand Campus, London WC2R 2LS, England

关键词: Ascorbic acid;    Myeloperoxidase;    Hypochlorous acid;    Superoxide;    Hydroxyl radical;    Neutrophil;   

DOI  :  10.1016/0014-5793(87)81456-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect α₁-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.

【 授权许可】

Unknown