Biogenesis of liver δ‐aminolevulmate synthase

FEBS Letters

Friedland, David M.¹  Ades, Ibrahim Z.¹ 

[1] Laboratories of Cell Biology, Department of Zoology, University of Maryland, College Park, MD 20742, USA

关键词: δ-Aminolevulinate synthase;    cAMP;    Hepatocyte culture;   

DOI  :  10.1016/0014-5793(85)81005-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In primary cultures of chick embryo hepatocytes pulse labeled with [³⁵S]methionine, immunochemical analyses indicated that adenosine 3':5'-cyclic monophosphate (cAMP) did not affect either the rate of production or the maturation of δ-aminolevulinate synthase (ALA synthase). In addition, allylisopropylacetamide caused a slight drop in intracellular cAMP while testosterone caused the levels of cAMP to rise to 260% of the basal levels measured in hepatocytes in culture. Thus the results of this study did not indicate a direct short-term role for cAMP in the regulation of production of ALA synthase.

【 授权许可】

Unknown