Developmental changes of gene expression in heme metabolic enzymes in rat placenta

FEBS Letters

Ejiri, Kohei³  Fujita, Hiroyoshi¹  Furuyama, Kazumichi¹  Kudo, Takafumi³  Akagi, Reiko²  Ihara, Naomi³ 

[1] Departments of Molecular Biology and Biochemistry, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-0872, Japan;Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja 719-1197, Japan;Department of Obstetrics and Gynecology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-0914, Japan

关键词: Placenta;    Trophoblast;    Fetus;    Heme;    δ-Aminolevulinate synthase;    Heme oxygenase;    Hypoxia;   

DOI  :  10.1016/S0014-5793(98)01324-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transcription levels of the non-specific δ-aminolevulinate synthase (ALAS-N) and heme oxygenase-1 (HO-1) in the placenta at the terminal stage of pregnancy were comparable to those in the female adult liver and in the spleen, respectively. Immunohistochemical studies demonstrated that both enzymes were exclusively expressed in the trophoblast. During gestation, transcript of ALAS-N slightly increased, while HO-1 mRNA significantly decreased. Induced acute fetal hypoxia resulted in an increase in ALAS-N mRNA and in a decrease in HO-1 mRNA. These findings indicate that placental heme metabolism is influenced by the oxygen supply.

【 授权许可】

Unknown