Active oxygen forms in photoreaction between DNA and furanochromones khellin and visnagin

FEBS Letters

Martelli, P.¹  Ferri, S.¹  Franchi, G.G.¹  Bari, M.¹  Bovalini, L¹ 

[1] Istituto di Chimica Biologica, Pian dei Mantellini 44, Università, 53100 Siena, Italy

关键词: Active oxygen;    Khellin;    Visnagin;    Fwanochromone;    DNA photoadduct;    Ultraviolet radiation;   

DOI  :  10.1016/0014-5793(85)81034-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The two furanochromones khellin and visnagin react with DNA under irradiation by 365 nm light, forming photoadducts. Recently, the use of khellin as therapeutic agent for skin diseases has been proposed. It is well known that during the formation of photoadducts toxic active oxygen forms are produced. We studied therefore the behaviour of the two furanochromones as producers of ¹O⁻ ₂, and O⁻ ₂ results indicate that visnagin is a strong generator of both Superoxide radicals and singlet oxygen, while khellin does not exhibit strong production of 00 ⁻ ₂ which is promptly quenched by Superoxide dismutase.

【 授权许可】

Unknown