Synthesis of 1,3‐dihydroxy‐N‐methylacridone by cell‐free extracts of Ruta graveolens cell suspension cultures

FEBS Letters

Baumert, A.¹  Gröger, D.¹ 

[1] Institute of Plant Biochemistry, Academy of Sciences of the GDR, DDR-4020 Halle (Saale), Weinberg 3, GDR

关键词: Ruta graveolens;    Cell-free extract;    Biosynthesis;    1;    3-Dihydroxy-N-methylacridone;   

DOI  :  10.1016/0014-5793(85)81266-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cell-free extracts of Ruta graveolens cell suspension cultures obtained after (NH₄)₂SO₄ precipitation and gel filtration on Sephadex G-25 catalyze the condensation of N-methylanthranilic acid and malonyl-CoA in the presence of ATP. The reaction product has been identified as 1,3-dihydroxy-N-methylacridone. This alkaloid 6 is apparently the key intermediate in the pathway leading to more complex acridone alkaloids.

【 授权许可】

Unknown