Subtype ayw variant of hepatitis B virus

FEBS Letters

Dreilina, D.¹  Pushko, P.¹  Pumpen, P.¹  Gren, E.¹  Bichko, V.¹ 

[1] Institute of Organic Synthesis, Latvian SSR Academy of Sciences, Aizkraukles 21, Riga, USSR

关键词: Hepatitis B virus;    DNA sequence;    Genetic variation;    Evolution;    bp;    base pairs;   

DOI  :  10.1016/0014-5793(85)80771-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The entire genome of human hepatitis B virus (HBV) occurring in Latvia was sequenced. This sequence, which is 3182 nucleotides long, was compared with the other previously published HBV genomes and was shown to share maximum homology with HBV subtype ayw DNA. The coordinates of 4 main open reading frames as well as hairpin structures are very well conserved in the two genomes. The distribution of nucleotide substitutions among different HBV genomes suggests that the open reading frames P and X can fulfil a coding function. On the basis of primary stucture comparison for hepadnaviral DNAs several evolutionary conclusions can be drawn.

【 授权许可】

Unknown