Mefloquine: an antimalarial drug interacting with the b/c region of bacterial respiratory chains

FEBS Letters

Zannoni, D.¹ 

[1] Institute of Botany, University of Bologna, 40126 Bologna, Italy

关键词: Mefloquine;    Electron transport;    Alternative oxidase;    Rhodopseudomonas capsulata;    Rhodopseudomonas sphaeroides;    Pseudomonas cichorii;   

DOI  :  10.1016/0014-5793(85)80806-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of mefloquine, a quinoline-4-methanol antimalarial drug, on respiration by various bacterial strains endowed with branched electron transport pathways, have been examined. It is concluded that mefloquine strongly interacts with cytochrome b in the b/c segment of the chain. Unlike myxothiazol, mefloquine does not inhibit oxidant-induced b-type reduction but does induce an extra cytochrome b reduction when used in combination with antimycin A. The data reported are interpreted as evidence that mefloquine inhibits a ubiquinol oxidase site in common to both the alternative oxidase and the b/c oxidoreductase complex of the chain.

【 授权许可】

Unknown