FEBS Letters | |
Mefloquine: an antimalarial drug interacting with the b/c region of bacterial respiratory chains | |
Zannoni, D.1  | |
[1] Institute of Botany, University of Bologna, 40126 Bologna, Italy | |
关键词: Mefloquine; Electron transport; Alternative oxidase; Rhodopseudomonas capsulata; Rhodopseudomonas sphaeroides; Pseudomonas cichorii; | |
DOI : 10.1016/0014-5793(85)80806-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The effects of mefloquine, a quinoline-4-methanol antimalarial drug, on respiration by various bacterial strains endowed with branched electron transport pathways, have been examined. It is concluded that mefloquine strongly interacts with cytochrome b in the b/c segment of the chain. Unlike myxothiazol, mefloquine does not inhibit oxidant-induced b-type reduction but does induce an extra cytochrome b reduction when used in combination with antimycin A. The data reported are interpreted as evidence that mefloquine inhibits a ubiquinol oxidase site in common to both the alternative oxidase and the b/c oxidoreductase complex of the chain.
【 授权许可】
Unknown
【 预 览 】
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