Modulation of a major 30‐kDa skeletal muscle protein by thyroid hormone

FEBS Letters

Tremblay, Roland R.¹  Ho-Kim, My Anh¹  Gagnon, Jacques¹  Champagne, Chantal¹  Rogers, Peter A.² 

[1] Laboratoire d'Endocrinologie-Métabolisme, Le Centre Hospitalier de l'Université Laval, 2705, Boul. Laurier, Québec G1V 4G2 Canada;Laboratoire des Sciences de l'Activité Physique, Université Laval, Québec G1K, 7P4, Canada

关键词: Thyroidectomy;    Fiber type;    Soleus muscle;    Protein synthesis;    Soluble enzyme;    Triiodothyronine;    IEF;    isoelectric focusing;    NEpHGE;    nonequilibrium pH gradient electrophoresis;    SDS-PAGE;    SDS-polyacrylamide gel electrophoresis;   

DOI  :  10.1016/0014-5793(85)81098-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Thyroidectomy results in the transformation of type II fibres to type I in rat soleus muscle. In vitro translations containing polyribosomes indicate that the template activity of mRNA coding for a 30-kDa protein is increased in hypothyroid (6 months) rats. The cellular content of this protein is also increased in hypothyroid rats. The in vitro synthesis of the 30-kDa protein is not observed in thyroidectomized (10 weeks) rats that have been treated with triiodothyronine. The synthesis and accumulation of this protein are directly related to the proportion of type I fibres in rat skeletal muscle and appear to be modulated by thyroid hormone.

【 授权许可】

Unknown