Proteolysis of liver acetyl coenzyme A carboxylase by cathepsin B

FEBS Letters

Tanabe, Tadashi¹  Wada, Kenji¹ 

[1] Laboratory of Cell Biology, National Cardiovascular Center Research Institute, Fujishiro-dai, Suita, Osaka 565, Japan

关键词: Protein degradation;    Acetyl-CoA carboxylase;    Cathepsin B;   

DOI  :  10.1016/0014-5793(85)80234-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Proteolysis of acetyl-CoA carboxylase was examined with cathepsin B. When chicken liver acetyl-CoA carboxylase was incubated with cathepsin B at pH 6.3, the native 220-kDa polypeptide was primarily cleaved into two polypeptides of 125 and 115 kDa, and further degraded to polypeptides of 100–50 kDa.

【 授权许可】

Unknown