Regulation of neuropeptide Y (NPY) binding by guanine nucleotides in the rat cerebral cortex

FEBS Letters

Bartfai, Tamas¹  Undén, Anders¹ 

[1] Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden

关键词: Neuropeptide Y;    Neuropeptide Y-receptor;    GTP;   

DOI  :  10.1016/0014-5793(84)80995-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the presence of GTP, GDP, GMPP(NH)P, GMPP(CH₂)P, GMPP(S)P but not in the presence of GMP, cGMP or ATP, the high affinity binding of neuropeptide Y (NPY) was reduced in a dose-dependent manner. GTP (0.1 mM) diminished the maximal binding capacity for ¹²⁵I-labelled NPY by 40% without any change in the equilibrium dissociation constant of the receptor ¹²⁵I-labelled NPY complex.

【 授权许可】

Unknown