Enhanced casein kinase II activity in human tumour cell cultures

FEBS Letters

Prowald, Katja¹  Fischer, Hans²  Issinger, Olaf-Georg¹ 

[1] Institut für Humangenetik, Universität des Saarlandes, D-6650 Homburg-3 FRG;Institut für Virusforschung, Deutsches Krebsforschungszentrum D-6900 Heidelberg, FRG

关键词: Casein kinase;    Human;    Tumor cell culture;    Phosphorylation;    Transformation;   

DOI  :  10.1016/0014-5793(84)81222-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Casein kinase II (CKII) activity is enhanced as much as 2–3 fold in established and 4–5-fold in transformed human cell lines when compared to that of fibroblasts and primary human tumour cell cultures where CKII activity never exceeded a basic level. The high activity of CKII in transformed cells and in established cell lines was reduced to about the same basic level after treatment with heparin, a highly specific inhibitor of CKII activity. The activity of the cAMP-dependent protein kinase was virtually the same in fibroblasts and various human tumour cell lines investigated.

【 授权许可】

Unknown