Lack of a direct role for cyclic AMP in parathyrin action on phosphate reabsorption by the kidney

FEBS Letters

Butterworth, Peter J.¹  Parveen, Riffat¹  Grahn, Michael F.¹ 

[1] Department of Biochemistry, Chelsea College, Manresa Road, London SW3 6LX, England

关键词: Kidney tubule;    Parathyroid hormone;    Cyclic AMP;    Phosphate transport;    PTH;    parathyroid hormone;   

DOI  :  10.1016/0014-5793(84)80945-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Isolated chick kidney proximal tubule cells have been used in a study of the mechanism by which PTH inhibits Na⁺-dependent P_i transport in the kidney. Treatment with PTH inhibits P_i uptake by the cells by 13% and stimulates cyclic AMP production by 77%. Forskolin, a potent activator of adenyl cyclase, brought about an 11-fold stimulation of cyclic AMP production by the cells, but in contrast to PTH, the drug had no effect on Na⁺-dependent P_i uptake. These results provide evidence that PTH action on phosphate transport is not mediated by cyclic AMP.

【 授权许可】

Unknown