The effects of parathyroid hormone on L‐type voltage‐dependent calcium channel currents in vascular smooth muscle cells and ventricular myocytes are mediated by a cyclic AMP dependent mechanism

FEBS Letters

Pang, Peter K.T.¹  Karpinski, Edward¹  Wu, Lingyun¹  Wang, Rui¹ 

[1] Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

关键词: Calcium channel;    Parathyroid hormone;    Cyclic AMP;    Vascular smooth muscle cell (rat);    Ventricular myocyte (rat);   

DOI  :  10.1016/0014-5793(91)80507-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present study demonstrated that L channel currents were decreased in smooth muscle cells, and increased in ventricular myocytes by both bovine parathyroid hormone, (bPTH-(1–34)), and dibutyryl cyclic AMP (db-cAMP), using the whole cell version of the patch clamp technique with Ba²⁺ as the charge carrier. The effects of bPTH-(1–34) and db-cAMP on L channel currents were additive but not synergistic. Furthermore, the effects of bPTH-(1–34) on L channel currents in these 2 cell preparations were abolished in the presence of a cAMP antagonist. These results suggest that the effects of bPTH-(1–34) on L channel currents in vascular smooth muscle cells and ventricular myocytes are mediated by a cAMP-dependent mechanism.

【 授权许可】

Unknown