Transfer of ferritin‐bound iron to adriamycin

FEBS Letters

Demant, Erland J.F.¹ 

[1] Department of Biochemistry C, Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark

关键词: Ferritin;    Adriamycin-Fe3+ complex;    Lipid peroxidation;    Submitochondrial particle;   

DOI  :  10.1016/0014-5793(84)80919-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interactions of adriamycin with ferritin-bound iron have been investigated. It is demonstrated (i) that adriamycin stimulates an iron-dependent lipid peroxidation in submitochondrial particles in the presence of ferritin, and (ii) that incubation of adriamycin with ferritin results in a slow transfer of iron to adriamycin with formation of an adriamycin-iron complex. The results are discussed in relation to the possible role for intracellular iron in adriamycin toxicity.

【 授权许可】

Unknown