Increased insulin sensitivity in soleus muscle from cold‐exposed rats: reversal by an adenosine‐receptor agonist

FEBS Letters

Budohoski, Leszek¹  Challiss, R.A.John¹  Newsholme, Eric A.¹  Lozeman, Fred J.¹  McManus, Bronwyn¹ 

[1] Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England

关键词: Cold-exposure;    Cold-acclimation;    Insulin sensitivity;    2-Chloroadenosine;    Muscle;   

DOI  :  10.1016/0014-5793(84)80777-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of 0.5,2,7 and 14 days cold exposure at 4°C on insulin sensitivity was investigated in the stripped soleus muscle preparation incubated in vitro. Cold-exposure for 2 or 7 days increased the sensitivity of glycolysis, but did not affect the sensitivity of glycogen synthesis to insulin. Cold-exposure for 0.5 or 14 days had no effect on the sensitivity of either process to insulin. The increased sensitivity to insulin after exposure of animals to the cold for 2 days was completely reversed by addition of the adenosine receptor agonist, 2-chloroadenosine, to the incubation medium. This suggests that cold exposure may increase insulin sensitivity in the muscle, either by a decrease in the concentration of adenosine in the muscle, or by a decrease in the number or affinity of the adenosine receptors.

【 授权许可】

Unknown