Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat

FEBS Letters

Budohoski, Leszek¹  Newsholme, Eric A.¹  John Challis, R.A.¹  McManus, Bronwyn¹ 

[1] Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England

关键词: Glycolysis;    Insulin sensitivity;    Insulin resistance;    Glycogen synthesis;    N 6-Phenylisopropyladenosine;    2-Chloroadenosine;    Isobutylmethyl xanthine;    8-Phenyltheophylline;   

DOI  :  10.1016/0014-5793(84)80820-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The concentration of insulin that produces half-maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2-chloroadenosine and N ⁶-phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8-phenyltheophylline. 2-Chloroadenosine increases the concentration of insulin required to stimulate glycolysis half maximally, from about 100 to 2000 μunits/ml. 8-Phenyltheophylline decreases this concentration of insulin from about 100 to 10 μunits/ml, an effect which is similar to that produced either by addition of adenosine deaminase to the medium or to exercise-training of the donor animals for 4 weeks.

【 授权许可】

Unknown