Prediction structure type for human leukocyte Interferon subtype A from circular dichroism

FEBS Letters

Manavalan, P.¹  Johnston, Paul D.²  Johnson, W.Curtis¹ 

[1] Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA;Protein Biochemistry Department, Genentech, Inc., 460 Pt. San Bruno Boulevard, South San Francisco, CA 94080, USA

关键词: Circu1lar dichroism;    Protein secondary structure;    Interferon;    Tertiary fold;   

DOI  :  10.1016/0014-5793(84)80741-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Vacuum UV circular dichroism studies were carried out on human leukocyte interferon subtype A. The secondary structure analysis for the CD spectrum shows 59% α-helix, 16% antiparallel β-sheet, no parallel β-sheet, 18% β-turns and 13% other structures. The analysis of the CD features for the prediction of tertiary structural class reveals that it is an all-α type protein.

【 授权许可】

Unknown