Induction of TNF‐like factor by murine macrophage‐like cell line J774.1 on treatment with Sarcophaga lectin

FEBS Letters

Natori, Shunji¹  Itoh, Akira¹  Iizuka, Keiko¹ 

[1] Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan

关键词: Tumor necrosis factor;    Sarcophaga;    lectin;    Macrophage;    J774.1;   

DOI  :  10.1016/0014-5793(84)80569-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

On stimulation with Sarcophaga lectin, the mouse macrophage-like cell line J774.1 secreted a factor like the tumor necrosis factor (TNF) into the culture medium. This factor was a protein with a molecular weight of 40000–45000, and was cytotoxic to L-929 cells, but not to normal embryonic fibroblasts. This factor was effective on both the ascites form and solid form of sarcoma 180 transplanted into ICR mice.

【 授权许可】

Unknown