FEBS Letters | |
Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin‐induced K+ release from red blood cells | |
Nagase, Hiromi1  Ozaki, Hiroshi1  Urakawa, Norimoto1  | |
[1] Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan | |
关键词: Palytoxin; Cardiac glycoside; K+ release; Red blood cell; (Na+ + K+)-ATPase; | |
DOI : 10.1016/0014-5793(84)81045-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Palytoxin (PTX), a highly toxic and sugar-containing substance isolated from Palythoa tuberculosa, caused K+ release from rabbit red blood cells. Cardiac glycosides, such as ouabain, convallatoxin, cymarin, digoxin and digitoxin, inhibited the PTX-induced K+ release. Their corresponding aglycones did not inhibit the K+ release, but antagonized the inhibitory effect of the glycosides. All these cardiotonic steroids equally inhibited the activity of (Na+ + K+-ATPase prepared from hog cerebral cortex. These results suggest that the sugar moiety of the cardiac glycosides is important for the inhibitory effect on the K+ release induced by PTX and that the inhibition is not related to their inhibitory potency on the (Na+ + K+)-ATPase activity.
【 授权许可】
Unknown
【 预 览 】
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