Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin‐induced K+ release from red blood cells

FEBS Letters

Nagase, Hiromi¹  Ozaki, Hiroshi¹  Urakawa, Norimoto¹ 

[1] Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan

关键词: Palytoxin;    Cardiac glycoside;    K+ release;    Red blood cell;    (Na+ + K+)-ATPase;   

DOI  :  10.1016/0014-5793(84)81045-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Palytoxin (PTX), a highly toxic and sugar-containing substance isolated from Palythoa tuberculosa, caused K⁺ release from rabbit red blood cells. Cardiac glycosides, such as ouabain, convallatoxin, cymarin, digoxin and digitoxin, inhibited the PTX-induced K⁺ release. Their corresponding aglycones did not inhibit the K⁺ release, but antagonized the inhibitory effect of the glycosides. All these cardiotonic steroids equally inhibited the activity of (Na⁺ + K⁺-ATPase prepared from hog cerebral cortex. These results suggest that the sugar moiety of the cardiac glycosides is important for the inhibitory effect on the K⁺ release induced by PTX and that the inhibition is not related to their inhibitory potency on the (Na⁺ + K⁺)-ATPase activity.

【 授权许可】

Unknown