Effect of Photon Radiations in Semi-Rigid Artificial Tissue Sensitized by Protoporphyrin IX Encapsulated with Silica Nanoparticles

2nd International Conference on Advanced Materials

Makhadmeh, Ghaseb N.^1,3,4 ; Aziz, Azlan Abdul^1,3 ; Abdul Razak, Khairunisak^2,3 ; Al-Akhras, M-Ali H.^5

School of Physics, Universiti Sains Malaysia, Penang, Malaysia^1

School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Penang, Malaysia^2

NanoBiotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia^3

Arts and Science College, Amman Arab University, Amman, Jordan^4

Bio-Medical Physics Laboratory, Department of Physics, Jordan University of Science and Technology, Irbid, Jordan^5

关键词: Artificial tissues;    Comparative analysis;    Light exposure;    Optical characteristics;    Optical features;    Photon radiation;    Protoporphyrin IX;    Red blood cell;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/305/1/012014/pdf
DOI  :  10.1088/1757-899X/305/1/012014

来源: IOP

【 摘 要 】

This study involves the synthesis of Protoporphyrin IX (PpIX) encapsulated with Silica Nanoparticles (SiNPs) as an application for Photodynamic therapy. Semi-rigid artificial tissues with optical features similar to human tissue were used as sample materials to ascertain the efficacy of PpIX encapsulated with SiNPs. The disparity in optical characteristics (transmittance, reflectance, scattering, and absorption) of tissues treated with encapsulated PpIX and naked PpIX under light exposure (Intensity at 408 nm ∼1.19 mW/cm2) was explored. The optimal exposure times required for naked PpIX and SiNPs encapsulated PpIX to engulf Red Blood Cells (RBCs) in the artificial tissue were subsequently measured. Comparative analysis showed that the encapsulated PpIX has a 91.5 % higher efficacy than naked PpIX. The results prove the applicability of PpIX encapsulated with SiNP on artificial tissue and possible use on human tissue.