Basement membrane heparan sulfate proteoglycan from the L2 rat yolk sac carcinoma

FEBS Letters

Fenger, Mogens¹  Wewer, Ulla²  Albrechtsen, Reidar² 

[1] The Department of Clinical Chemistry, Rigshospitalet, Blegdamsvej 9 Copenhagen, Denmark;The University Institute of Pathological Anatomy, DK-2100 Copenhagen, Denmark

关键词: Basement membrane;    Proteoglycan;    Heparan sulfate;    Yolk sac carcinoma;   

DOI  :  10.1016/0014-5793(84)81020-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Heparan sulfate proteoglycan from the L2 rat yolk sac carcinoma has been purified and partially characterized. The proteoglycan has an apparent M _r of 750000, 35% of which represents the core protein. The core protein seems to be homogeneous, whereas the heparan sulfate chains are heterogeneous with an M _r of about 50000–70000, with 30% of the glucosamine being N-sulfated. Antibodies raised against the core protein of the heparan sulfate proteoglycan reacted with basement membranes of various rat and human tissue.

【 授权许可】

Unknown