Thyroxine preferentially stimulates transcription by isolated neuronal nuclei in the developing rat brain cortex

FEBS Letters

Lindholm, Dan B.¹ 

[1] Department of Medical Chemistry, University of Helsinki, Siltavuorenpenger 10 A, SF-00170 Helsinki 17, Finland

关键词: Thyroid hormone;    Development;    Rat brain cortex;    Brain cell nucleus;    RNA polymerase;    Micrococcal nuclease;   

DOI  :  10.1016/0014-5793(84)80495-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The administration of thyroxine to neonatal rats stimulates RNA synthesis by neuronal nuclei isolated from the developing rat brain cortex. Glial nuclei are relatively resistant to thyroxine treatment. The activity of neuronal RNA polymerase II is particularly stimulated by the hormone. Thyroxine also affects neuronal chromatin structure as shown by changes in the relative proportion of different subnuclear fractions obtained by gentle micrococcal nuclease digestion of nuclei from hormone-treated rats.

【 授权许可】

Unknown