Opposite regulations by androgenic and thyroid hormones of V1 myosin expression in the two types of rabbit striated muscle: skeletal and cardiac

FEBS Letters

Couteaux, René²  Mira, Jean-Claude¹  d'Albis, Anne³  Janmot, Chantal³ 

[1] Laboratoire de Neurobiologie, Université René Descartes, Paris, France;Institut des Neurosciences du CNRS, Département de Cytologie, Université Pierre et Marie Curie, Paris, France;Laboratoire de Biologie Physico-chimique, URA CNRS 1131, Université Paris-Sud, Orsay, France

关键词: Cardiac V1 myosin;    Thyroid hormone;    Androgenic hormone;    Masticatory muscle;    Development;    Rabbit muscle;   

DOI  :  10.1016/0014-5793(93)81326-U

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The finding that VI cardiac myosin is expressed in masticatory skeletal muscles of the rabbit [1] provided a unique opportunity for comparing the hormonal regulation of VI in skeletal and cardiac muscles. Thyroid hormones had no significant effect on the postnatal expression of VI in masticatory muscles, but increased this expression in cardiac ventricles. In contrast, androgenic hormones reduced VI expression in masticatory muscles, but did not affect it significantly in cardiac ventricles. Modulation of VI gene transcription in striated muscle is thus shown here to depend both on the target muscle and on the hormone.

【 授权许可】

Unknown