Primary sequence differences between Chido and Rodgers variants of tryptic C4d of the human complement system

FEBS Letters

Lundwall, Åke¹  Hellman, Ulf¹  Eggertsen, Gösta¹  Sjöquist, John¹  Engström, Åke¹ 

[1] Department of Medical Physiological Chemistry, PO Box 575, S-751 23 Uppsala, Sweden

关键词: Complement;    Human C4d;    Sequence;    Polymorphism;    Blood group;   

DOI  :  10.1016/0014-5793(84)81323-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human tryptic C4d of the Chido and Rodgers variant was fragmented by cyanogen bromide and trypsin. The fragments were characterized by amino acid analysis and sequence determination. Polymorphism between the two genetic variants was detected in 5 positions. Four were closely located (residues 141, 142, 145, 146), where Leu, Ser, Ile, His occurred in the Chido variant and Pro, Cys, Leu, Asp in the Rodgers variant, respectively. In position 94 Gly was found in Chido and Asp in Rodgers. Alignment of the fragments was performed and it is concluded that tryptic C4d of both variants contains 346 residues.

【 授权许可】

Unknown