Sodium butyrate inhibits the synthesis of the transformation related protein p 53 in 3T6 mouse fibroblasts

FEBS Letters

Mudrak, Ingrid¹  Wintersberger, Erhard¹ 

[1] Institut für Molekularbiologie der Universität Wien, Wasagasse 9, A-1090 Wien, Austria

关键词: Cell cycle;    G1/S transition;    3T6 cell;    SV 40 transformed cell;    Transformation related protein;    Monoclonal antibody;   

DOI  :  10.1016/0014-5793(84)80105-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sodium butyrate, which blocks the cell cycle of many cell types in the G₁ phase, strongly inhibits the synthesis of the transformation related, 53 kDa protein in 3T6 fibroblasts but much less so in SV 40 transformed mouse cells. By several criteria, this effect of the fatty acid appears to be indirect; p 53 synthesis takes place several hours after the butyrate-sensitive step in G₁. The results are discussed in the light of a putative role of p 53 in growth control.

【 授权许可】

Unknown