Pancreatic secretory factor (PSF), a protein from Gila monster venom stimulating enzyme secretion from rat pancreatic acini

FEBS Letters

Winand, Jacques¹  Vandermeers, André¹  Vandermeers-Piret, Marie-Claire¹  Christophe, Jean¹  Waelbroeck, Magali¹  Dehaye, Jean-Paul¹  Michel, Patrick¹  Robberecht, Patrick¹ 

[1] Department of Biochemistry and Nutrition, Medical School, Université Libre de Bruxelles, Bld. de Waterloo 115, B-1000 Brussels, Belgium

关键词: Gila monster venom;    Pancreatic secretory factor;    Scretin;    Vasoactive intestinal peptide;    Cholecystokinin;    Bombesin;    Carbamylcholine;    Cyclic AMP;    Calcium efflux;    Stimulus-secretion coupling;    PSF;    pancreatic secretory factor;    CCK-8;    C-terminal octapeptide of cholecystokinin-pancreozymin;   

DOI  :  10.1016/0014-5793(84)80096-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pancreatic secretory factor (PSF), a 17.5-kDa protein purified from the venom of Gila monster (Heloderma suspectum), stimulated amylase secretion from dispersed rat pancreatic acini more efficiently than CCK-8, bombesin, carbachol and secretin, and without increasing ⁴⁵Ca²⁺ efflux and cyclic AMP levels. The secretory action was dependent on the presence of extracellular calcium and was additive to the secretion induced by agents acting via cyclic AMP or via Ca²⁺ efflux.

【 授权许可】

Unknown