Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of biological properties

FEBS Letters

Winand, Jacques¹  Vandermeers, André¹  Vandermeers-Piret, Marie-Claire¹  Christophe, Jean¹  Waelbroeck, Magali¹  Dehaye, Jean-Paul¹  Robberecht, Patrick¹ 

[1] Department of Biochemistry and Nutrition, Medical School, Université Libre de Bruxelles, Bld de Waterloo 115, B-1000 Brussels, Belgium

关键词: Gila monster venom;    Helodermin;    Secretin;    Vasoactive intestinal peptide;    Bombesin;    Adenylate cyclase;    VIP;    vasoactive intestinal peptide;    PHI;    peptide having an N-terminal histidine and a C-terminal isoleucine amide;   

DOI  :  10.1016/0014-5793(84)80095-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Helodermin, a newly isolated peptide from the venom of Gila monster (Heloderma suspectum) was shown to stimulate the adenylate cyclase activity of rat pancreatic membranes as effectively as secretin and VIP. It also increased cyclic AMP levels and inhibited [¹²⁵I]VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate cyclase in membranes from rat heart, rat brain, and human heart, showing properties analogous yet distinct from those of secretin, VIP and PHI.

【 授权许可】

Unknown