New potent inhibitors of angiotensin converting enzyme

FEBS Letters

Francis, R.John¹  Natoff, Ian L.¹  Redshaw, Sally¹  Hassall, Cedric H.¹  Nixon, John S.¹  Lawton, Geoffrey¹  Kröhn, Antonin¹  Thomas, W.Anthony¹  Attwood, Michael R.¹ 

[1] Roche Products Limited, PO Box 8, Welwyn Garden City, Herts, AL7 3AY, England

关键词: Angiotensin-converting enzyme;    Inhibitor;    Design;    Antihypertensive;   

DOI  :  10.1016/0014-5793(84)80169-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using an earlier model of the favoured orientation of binding functions of angiotensin converting enzyme (ACE) inhibitors, it has been possible to postulate a new, 7,6-bicyclic system, based on hexahydropyridazine, which might be expected to have high potency. Some members of this system which have been synthesised have been shown to be very active ACE inhibitors, in vitro and in vivo.

【 授权许可】

Unknown