Inter‐alpha‐trypsin‐inhibitor (ITI): two distinct mRNAs in baboon liver argue for a discrete synthesis of ITI and ITI derivatives

FEBS Letters

Martin, J.P.¹  Vercaigne, D.¹  Sesboüé, R.¹  Salier, J.P.¹  Bourguignon, J.¹ 

[1] Inserm Unité 78, F-76230 Bois-Guillaume, France

关键词: Inter-alpha-trypsin-inhibitor;    Serum protease inhibitor;    mRNA translation;    Protein structure;    Baboon;    ITI;    inter-alpha-rypsin inhibitor;    HI-14/HI-30;    human ITI C-terminal (14/30 kDa) inhibitory active parts;    UID;    urinary ITI derivative;    NHS;    normal human serum;    SDS—PAGE;    sodium dodecyl sulfate—polyacrylamide gel electrophoresis;    CIE;    crossed immunoelectrophoresis;   

DOI  :  10.1016/0014-5793(83)80791-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human serum inter-alpha-trypsin-inhibitor (ITI) has so far been assumed to be comprised of a single polypeptide chain which can undergo fragmentation, whereby inhibitory ITI derivatives are released into the blood stream. It contrast, the analysis of the baboon liver mRNA translation products showed that ITI is made up of heavy and light chain(s). The latter may be excreted independently and very likely corresponds to the so-called ITI derivatives.

【 授权许可】

Unknown