Hot topics in aging research: protein translation and TOR signaling, 2010

Aging Cell

Matt Kaeberlein¹ 

[1] Department of Pathology, University of Washington, Seattle, WA 98195, USA

关键词: TORC1;    mTOR;    S6K1;    rapamycin;    longevity;    dietary restriction;    mRNA translation;    ribosome;   

DOI  :  10.1111/j.1474-9726.2010.00665.x

来源: Wiley

【 摘 要 】

Summary

In this, the fourth installment of our annual Hot Topics review on mRNA translation and aging, we have decided to expand our scope to include recent findings related to the role of TOR signaling in aging. As new data emerge, it is clear that TOR signaling acts upstream of mRNA translation, as well as a variety of other cellular processes, to modulate longevity and healthspan in evolutionarily diverse species. This Hot Topics review will cover important new findings in this area that have occurred over the past year. These include the demonstration that the TOR substrate ribosomal S6 kinase modulates longevity in mammals, the potential for TOR inhibitors as therapeutic treatments for Alzheimer’s disease, and further studies emphasizing the importance of differential translation of specific mRNAs for healthy aging and enhanced longevity.

【 授权许可】

Unknown   
© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland