Messenger RNA activities of four acute phase proteins during inflammation

FEBS Letters

Andus, Tilo¹  Nagashima, Mariko²  Heinrich, Peter C.¹  Schreiber, Gerhard²  Northemann, Wolfgang¹  Gross, Volker¹ 

[1] Biochemisches Institut, Universität Freiburg, Hermann-Herder-Str. 7, D-7800 Freiburg i.Br., FRG;The Russel Grimwade School of Biochemistry, University of Melbourne, Parkville, VIC 3052, Australia

关键词: Acute phase protein;    Cell-free translation;    α2-Macroglobulin;    α1-Acid glycoprotein;    α1-Proteinase inhibitor;    Transferrin;    Rat serum albumin;   

DOI  :  10.1016/0014-5793(83)81033-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Poly(A)⁺ RNA isolated from the livers of normal rats and of rats suffering from an acute inflammation was translated in a cell-free translation system from rabbit reticulocytes. The translation products were immunoprecipitated with specific antisera against α1-acid glycoprotein, α2-macroglobulin, transferrin, α1-proteinase inhibitor and albumin. 15 to 21 h after intramuscular injection of turpentine 73-, 66-, 2.8-, and 2-fold increases in translatable mRNAs for α1-acid glycoprotein, α2-macroglobulin, transferrin and α1-proteinase inhibitor, respectively, were observed. For albumin a decrease in translatable mRNA to about 30% of controls was measured.

【 授权许可】

Unknown