Interleukin 1β modulates hepatic synthesis of α1‐acid glycoprotein in the fetal rat

FEBS Letters

Valencia, Richard¹  Bertaux, Odile¹  Durand, Dominique²  Durand, Geneviéve¹  Fournier, Thierry¹  Porquet, Dominique¹ 

[1]CNRS VA 622 and Laboratoire de Biochimie, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris XI, 5, rue J.B. Clément, 92296 Châtenay-Malabry Cédex, France

[2]Laboratoire d'Endocrinologie, UFR des Sciences Pharmaceutiques, Université Paris V, 4, av de l'Observatoire, 75270 Paris Cédex 06 France

关键词: Interleukin 1β;    α1-Acid glycoprotein;    Orosomucoid;    Fetal rat;   

DOI  :  10.1016/0014-5793(90)80716-V

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ability of the fetal rat to respond to interleukin 1β (IL1β) by expressing α1-acid glycoprotein (AGP) was investigated. Eight and 20 h after injection of 7 ng IL1β into 19-day fetuses, liver AGP mRNA increased by a factor of 66 and 82 respectively, while serum AGP levels increased by a factor of 3 and 5. Similar treatment of the mothers altered in the fetuses neither AGP serum levels nor the amount of liver AGP mRNA. The induction of AGP gene expression in the fetal liver in response to IL1β was similar to that observed in the adult liver. These results demonstrate that at day 19 the fetal rat liver has acquired a mature acute-phase system.

【 授权许可】

Unknown