期刊论文详细信息
FEBS Letters | |
Evidence that mAMSA induces topoisomerase action | |
Ralph, R.K.1  Darkin, S.1  Marshall, B.1  | |
[1] Department of Cell Biology, University of Auckland, Auckland, New Zealand | |
关键词: mAMSA; oAMSA; DNA fragmentation; Topoisomerase; | |
DOI : 10.1016/0014-5793(83)80733-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Evidence is presented that the topoisomerase inhibitors novobiocin and coumermycin inhibit the production of double-strand breaks in mouse mastocytoma cell nuclear DNA by the anticancer drug 4′[(9-acridinyl)amino]-methanesulphon-m-anisidide (mAMSA). Novobiocin did not inhibit resealing of DNA breaks induced by mAMSA. It is suggested that mAMSA intercalation into DNA induces the action of a type II topoisomerase. mAMSA and oAMSA were equally effective in breaking the DNA in isolated nuclei.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020284647ZK.pdf | 382KB | download |