Evidence that mAMSA induces topoisomerase action

FEBS Letters

Ralph, R.K.¹  Darkin, S.¹  Marshall, B.¹ 

[1] Department of Cell Biology, University of Auckland, Auckland, New Zealand

关键词: mAMSA;    oAMSA;    DNA fragmentation;    Topoisomerase;   

DOI  :  10.1016/0014-5793(83)80733-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is presented that the topoisomerase inhibitors novobiocin and coumermycin inhibit the production of double-strand breaks in mouse mastocytoma cell nuclear DNA by the anticancer drug 4′[(9-acridinyl)amino]-methanesulphon-m-anisidide (mAMSA). Novobiocin did not inhibit resealing of DNA breaks induced by mAMSA. It is suggested that mAMSA intercalation into DNA induces the action of a type II topoisomerase. mAMSA and oAMSA were equally effective in breaking the DNA in isolated nuclei.

【 授权许可】

Unknown