期刊论文详细信息
FEBS Letters
The effect of dichloroacetate and hydroxypyruvate on the entry of 14C from [1‐14C]alanine into urea in rat hepatocytes
Hems, Reginald1 
[1] Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, England
关键词: Urea synthesis;    Equilibration of metabolic CO2;    Dichloroacetate;    Hydroxypyruvate;    Mitochondrial pH gradient;    Hepatocyte;   
DOI  :  10.1016/0014-5793(83)80977-6
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Entry of metabolic 14CO2 into urea is shown to be decreased by dichloroacetate although the production of 14CO2 is stimulated 2-fold. Hydroxypyruvate, a product of dichloroacetate metabolism, increases the incorporation of metabolic 14CO2 into urea. It is proposed that these effects result from changes in the cytoplasmic-mitochondrial pH gradient.

【 授权许可】

Unknown   

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