Phospholamban of cardiac sarcoplasmic reticulum consists of two functionally distinct proteolipids

FEBS Letters

Carafoli, Ernesto¹  Chiesi, Michele¹  Gasser, Jürg¹ 

[1] Laboratory of Biochemistry, Swiss Federal Institute of Technology (ETH), 8092 Zürich, Switzerland

关键词: Sarcoplasmic reticulum;    Heart;    Phospholamban;    Calmodulin;    Cyclic AMP;    Phosphorylation;   

DOI  :  10.1016/0014-5793(83)80936-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Phosphorylation of phospholamban by either a cAMP-dependent or a calmodulin-dependent kinase stimulates the Ca²⁺ transporting activity of cardiac sarcoplasmic reticulum membranes. It has now been found that phospholamban consists of 2 distinct proteins; one is the specific substrate for the cAMP-dependent phosphorylation, and the other for the calmodulin-dependent kinase. In spite of functional diversity, the 2 polypeptides share a number of properties. Among them, the proteolipid character, M _r, resistance to trypsinization, and subunit composition.

【 授权许可】

Unknown