Vinculin localization in cardiac muscle

FEBS Letters

Koteliansky, V.E.¹  Gneushev, G.N.¹ 

[1] Institute of Experimental Cardiology, USSR Cardiology Research Center, Academy of Medical Sciences, Cherepkovskaya Str., 15A, 7, Moscow 121500, USSR

关键词: Cardiac muscle;    Vinculin;    Sarcolemma;    Immunofluorescence;    Sarcolemma—myofibril interaction;   

DOI  :  10.1016/0014-5793(83)80437-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Vinculin isolated from chicken cardiac muscle crossreacts with antibodies against smooth muscle vinculin. Antibodies to vinculin were used for localization of vinculin in cardiac muscle by indirect immunofluorescence method. In cardiac muscle vinculin was localized in intercalated discs and near plasma membrane at the cell periphery between external myofibrils and sarcolemma. It was suggested that vinculin plays an important role in myofibril—sarcolemma interaction in cardiac muscle

【 授权许可】

Unknown