Isolation and characterization of the mouse corticotropin‐β‐lipotropin precursor gene and a related pseudogene

FEBS Letters

Tobimatsu, Takamasa¹  Mishina, Masayoshi¹  Takahashi, Hideo¹  Numa, Shosaku¹  Notake, Mitsue¹  Watanabe, Yumiko¹ 

[1]Department of Medical Chemistry, Kyoto University Faculty of Medicine, Yoshida, Sakyo-ku, Kyoto 606, Japan

关键词: Mouse corticotropin-β-lipotropin precursor gene;    Pseudogene;    Recombinant DNA;    DNA sequence;    Exon/intron;    Direct repeat;    ACTH;    corticotropin;    β-LPH;    β-lipotropin;   

DOI  :  10.1016/0014-5793(83)80250-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two mouse genomic DNA sequences homologous with human corticotropin-β-lipotropin precursor gene sequences have been cloned. One of them represents the functional corticotropin-β-lipotropin precursor gene, which exhibits a structural organization similar to those of its bovine and human counterparts. The other represents a pseudogene that corresponds to the functional mouse gene sequence encoding the carboxy-terminal 143 amino acid residues (including corticotropin and β-lipotropin) and the 3′-untranslated region.

【 授权许可】

Unknown