Adenosine deaminase normalizes cyclic AMP responses of hypothyroid rat fat cells to forskolin, but not β‐adrenergic agonists

FEBS Letters

Graziano, Michael P.¹  Malbon, Craig C.¹ 

[1] Department of Pharmacological Sciences, Health Sciences Center, The State University of New York at Stony Brook, Stony Brook, NY 11794, USA

关键词: Hypothyroidism;    Cyclic AMP;    Forskolin;    β-Adrenergic agonist;    Adenosine deaminase;   

DOI  :  10.1016/0014-5793(83)80203-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lipolysis and cyclic AMP accumulation in response to β-adrenergic agonists or forskolin are severely impaired in fat cells from the hypothyroid rat. Incubating hypothyroid rat fat cells with adenosine deaminase normalizes the cyclic AMP response to forskolin, but not to β-adrenergic agonists. Increased sensitivity to adenosine action in the hypothyroid state appears to be the basis for the impaired cyclic AMP response to forskolin, but does not appear to be the underlying defect responsible for the impaired response to β-adrenergic agonists.

【 授权许可】

Unknown