Isolation of a brain peptide identical to the intestinal PHI (peptide HI)

FEBS Letters

Mutt, Viktor²  Carlquist, Mats²  Tatemoto, Kazuhiko²  McDonald, Thomas J.¹ 

[1] Department of Medicine, University of Western Ontario, London, Canada;Department of Biochemistry II, Karolinska Institute, S-104 01 Stockholm, Sweden

关键词: Brain—gut peptide;    Neuropeptide;    Glucagon—secretin family;    Amino acid sequence;    C-terminal amide;    Chemical assay;    PHI;    peptide HI (the peptide having N-terminal histidine and C-terminal isoleucine amide);    VIP;    vasoactive intestinal peptide;   

DOI  :  10.1016/0014-5793(83)80617-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The isolation of a brain peptide identical to the intestinal peptide PHI (peptide HI) is described. The peptide was isolated from porcine brain extract using a chemical assay method based on its C-terminal isoleucine amide structure. The complete amino acid sequence of the peptide was found to be: This sequence is identical to the intestinal peptide thus demonstrating PHI to be a brain-gut peptide. The role of PHI in the central nervous system as a neurotransmitter or neuromodulator is discussed.

【 授权许可】

Unknown