期刊论文详细信息
FEBS Letters | |
Isolation of a brain peptide identical to the intestinal PHI (peptide HI) | |
Mutt, Viktor2  Carlquist, Mats2  Tatemoto, Kazuhiko2  McDonald, Thomas J.1  | |
[1] Department of Medicine, University of Western Ontario, London, Canada;Department of Biochemistry II, Karolinska Institute, S-104 01 Stockholm, Sweden | |
关键词: Brain—gut peptide; Neuropeptide; Glucagon—secretin family; Amino acid sequence; C-terminal amide; Chemical assay; PHI; peptide HI (the peptide having N-terminal histidine and C-terminal isoleucine amide); VIP; vasoactive intestinal peptide; | |
DOI : 10.1016/0014-5793(83)80617-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The isolation of a brain peptide identical to the intestinal peptide PHI (peptide HI) is described. The peptide was isolated from porcine brain extract using a chemical assay method based on its C-terminal isoleucine amide structure. The complete amino acid sequence of the peptide was found to be: This sequence is identical to the intestinal peptide thus demonstrating PHI to be a brain-gut peptide. The role of PHI in the central nervous system as a neurotransmitter or neuromodulator is discussed.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020284054ZK.pdf | 352KB | download |