期刊论文详细信息
FEBS Letters | |
Malignant hyperthermia in pigs: A search for abnormalities in Ca2+ binding proteins | |
Lorkin, P.A.1  Lehmann, H.1  | |
[1] Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England | |
关键词: Muscular hyperthermia; Pig troponin C; Tryptic peptide mapping; Calmodulin; MH; malignant hyperthermia; Tn; troponin; 2-D; two-dimensional; DEAE; diethylaminoethyl; DTT; dithiothreitol; EGTA; ethyleneglycolbis (aminoethylether) tetra-acetic acid; SDS; sodium dodecyl sulphate; IEF; isoelectric focusing; A; absorbance; UV; ultraviolet; M r; relative molecular mass; T; tryptic peptide; R; electrophoretic mobility; | |
DOI : 10.1016/0014-5793(83)80123-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Malignant hyperthermia occurs in man and pigs as a hereditary disorder notably as a complication of halotane-induced anaesthesia. It involves an abnormality in the metabolism of Ca2+. A search was made for abnormalities of calcium-binding proteins. Troponin C from normal pig muscle was found to differ in 2 of 159 amino acids from rabbit Tn C and 3 from man. No differences between normal and abnormal pig muscle were found. Two-dimensional electrophoresis of red cell calmodulin from normal and abnormal pigs also failed to demonstrate a difference.
【 授权许可】
Unknown
【 预 览 】
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