Hb F Kingston (Gγ55 [D6] Met→Arg)

FEBS Letters

Serjeant, Beryl E.²  Dukes, Monica¹  Lehmann, H.¹  Robb, Laurene¹  Serjeant, G.R.² 

[1] UniversityDepartment of Biochemistry and Abnormal Haemoglobin Reference Service, Old Addenbrooke's Hospital, Cambridge, England;MRC Laboratories, University of the West Indies, Mona, Kingston, Jamaica, West Indies

关键词: Hb F Kingston;    Cord blood screening;    Fetal haemoglobin;    Chain Gγ;    Position γ55 (D6);    Tryptic peptide mapping;   

DOI  :  10.1016/0014-5793(82)81307-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A fetal haemoglobin variant was noted in a healthy Jamaican infant of mixed African/Chinese extraction. A two-dimensional chromatogram of the soluble tryptic peptides (Tp) showed 2 ‘new’ ones/ One was composed of the last 4 residues of the usually insoluble Tpγ41–59. To permit a tryptic split this required a change of residue γ55 Met to Lys or Arg. The other new Tp contained arginine and was in the position expected for a Tpγ41–55 (55 Arg). As the material was limited it could not be analysed. When after more than 6 years no example of Hb F Kingston had become available it was decided to describe the variant on the basis of the present evidence.

【 授权许可】

Unknown