FEBS Letters | |
Hb F Kingston (Gγ55 [D6] Met→Arg) | |
Serjeant, Beryl E.2  Dukes, Monica1  Lehmann, H.1  Robb, Laurene1  Serjeant, G.R.2  | |
[1] UniversityDepartment of Biochemistry and Abnormal Haemoglobin Reference Service, Old Addenbrooke's Hospital, Cambridge, England;MRC Laboratories, University of the West Indies, Mona, Kingston, Jamaica, West Indies | |
关键词: Hb F Kingston; Cord blood screening; Fetal haemoglobin; Chain Gγ; Position γ55 (D6); Tryptic peptide mapping; | |
DOI : 10.1016/0014-5793(82)81307-0 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A fetal haemoglobin variant was noted in a healthy Jamaican infant of mixed African/Chinese extraction. A two-dimensional chromatogram of the soluble tryptic peptides (Tp) showed 2 ‘new’ ones/ One was composed of the last 4 residues of the usually insoluble Tpγ41–59. To permit a tryptic split this required a change of residue γ55 Met to Lys or Arg. The other new Tp contained arginine and was in the position expected for a Tpγ41–55 (55 Arg). As the material was limited it could not be analysed. When after more than 6 years no example of Hb F Kingston had become available it was decided to describe the variant on the basis of the present evidence.
【 授权许可】
Unknown
【 预 览 】
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RO201912020283746ZK.pdf | 304KB | download |